Dispense 1/3 of the ampoule into the palm of your hand and massage it onto your skin, over the face and neck, avoiding the eye contour. Allow serum to be absorbed into your skin for 30-60 seconds before applying the rest of your skin care routine. Use 50+spf sun protection cream during the day. Place the cap back onto the applicator tip to preserve the formula until the next application. Use within 48 hours after opening. For more information, please read the instructions inside the box.